Dietary factors in experimental autoimmune encephalomyelitis and multiple sclerosis: A comprehensive review

Mult Scler. 2020 May 14;1352458520923955. doi: 10.1177/1352458520923955. Online ahead of print.


Background: Dietary intervention in multiple sclerosis carries potential therapeutic implications. While studies utilizing animal models of multiple sclerosis (MS) have demonstrated intriguing findings, well-designed clinical trials are few in number.

Objective: The objective of this study is to review the animal model and clinical literature regarding dietary factors in experimental autoimmune encephalitis (EAE) and MS.

Methods: This manuscript provides a comprehensive review of current animal model and clinical knowledge related to dietary factors in MS.

Results: While there is currently little data for any specific diet in MS, there is growing evidence that certain dietary factors may influence the disease.

Conclusions: Definitive information regarding dietary factors as a modifiable risk factor in MS will require larger randomized clinical trials.

Keywords: Multiple sclerosis; diet; diet therapy; environmental biomarkers; experimental autoimmune encephalitis; microbiota.