B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria

Virulence. 2020 Dec;11(1):594-606. doi: 10.1080/21505594.2020.1768329.

Abstract

Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear. Interferon lambda (IFNλ), a type III interferon, is a cytokine produced early during blood-stage malaria infection that has an unknown physiological role during malaria infection. We demonstrate that B cell-intrinsic IFNλ signals suppress the acute antibody response, acute plasmablast response, and impede acute parasite clearance during a primary blood-stage malaria infection. Our findings demonstrate a previously unappreciated role for B cell intrinsic IFNλ-signaling in the initiation of the humoral immune response in the host response to experimental malaria.

Keywords: Malaria; humoral immune response; interferon-λ; plasmodium; type III interferon.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antibodies, Protozoan / immunology
  • B-Lymphocytes / immunology*
  • Cytokines / immunology
  • Gene Deletion
  • Immunity, Humoral*
  • Interferons / immunology*
  • Malaria / blood
  • Malaria / immunology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Plasmodium yoelii / immunology
  • Receptors, Interferon / genetics*
  • Receptors, Interferon / immunology
  • Signal Transduction / immunology
  • Specific Pathogen-Free Organisms

Substances

  • Antibodies, Protozoan
  • Cytokines
  • Receptors, Interferon
  • interferon type III
  • Interferons