Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.
Keywords: COVID-19; MDSC; NK cells; cytotoxic cells; inflammation.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.