SARS-CoV-2: A New Song Recalls an Old Melody

Kanta Subbarao

doi:10.1016/j.chom.2020.04.019

SARS-CoV-2: A New Song Recalls an Old Melody

Cell Host Microbe. 2020 May 13;27(5):692-694. doi: 10.1016/j.chom.2020.04.019.

Author

Kanta Subbarao¹

Affiliation

¹ WHO Collaborating Centre for Reference and Research on Influenza and Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth Street, Melbourne, VIC 3000, Australia. Electronic address: kanta.subbarao@influenzacenter.org.

Abstract

The viruses causing the SARS outbreak of 2002-2003 and current COVID-19 pandemic are related betacoronaviruses. What insights were learned from SARS that can inform SARS-CoV-2 vaccine development? Focusing on important lessons from SARS vaccine development and two SARS vaccines evaluated in humans may guide SARS-CoV-2 vaccine design, testing, and implementation.

Publication types

Review

MeSH terms

Animals
Antibodies, Neutralizing
Betacoronavirus / immunology*
COVID-19
COVID-19 Vaccines
Clinical Trials as Topic / standards
Coronavirus Infections / immunology*
Coronavirus Infections / prevention & control*
Humans
Pandemics / prevention & control*
Pneumonia, Viral / immunology*
Pneumonia, Viral / prevention & control*
SARS-CoV-2
Severe Acute Respiratory Syndrome / prevention & control
Severe acute respiratory syndrome-related coronavirus / immunology
Spike Glycoprotein, Coronavirus / immunology
Viral Vaccines / immunology*
Viral Vaccines / standards

Substances

Antibodies, Neutralizing
COVID-19 Vaccines
Spike Glycoprotein, Coronavirus
Viral Vaccines
spike protein, SARS-CoV-2