Rational Vaccine Design in the Time of COVID-19

Cell Host Microbe. 2020 May 13;27(5):695-698. doi: 10.1016/j.chom.2020.04.022.

Abstract

As scientists consider SARS-CoV-2 vaccine design, we discuss problems that may be encountered and how to tackle them by what we term "rational vaccine design." We further discuss approaches to pan-coronavirus vaccines. We draw on experiences from recent research on several viruses including HIV and influenza, as well as coronaviruses.

MeSH terms

  • AIDS Vaccines / immunology
  • AIDS Vaccines / standards
  • Antibodies, Viral / immunology*
  • Antigens, Viral / immunology*
  • Betacoronavirus / immunology*
  • COVID-19
  • COVID-19 Vaccines
  • Coronavirus Infections / immunology
  • Coronavirus Infections / prevention & control*
  • Humans
  • Influenza Vaccines / immunology
  • Influenza Vaccines / standards
  • Pandemics / prevention & control*
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / prevention & control*
  • Research Design / trends
  • SARS-CoV-2
  • Viral Vaccines / immunology*

Substances

  • AIDS Vaccines
  • Antibodies, Viral
  • Antigens, Viral
  • COVID-19 Vaccines
  • Influenza Vaccines
  • Viral Vaccines