Adenoid Cystic Carcinoma of Bartholin's Gland: What Is the Best Approach?

Oncology. 2020;98(8):513-519. doi: 10.1159/000506485. Epub 2020 May 14.


Background and summary: Among all vulvar cancers, primary adenoid cystic carcinoma (ACC) of Bartholin's gland is a very rare tumor characterized by a slow growth, a high local aggressiveness, and a remarkable recurrence rate. Due to its rarity, treatment remains a challenge for oncologists and gynecological surgeons. Key message: The present paper reports clinical, radiological, and histological features of ACC of Bartholin's gland and reviews the literature data on the treatment options with a particular focus on the potential role of particle radiation therapy.

Keywords: Adenoid cystic carcinoma; Chemoresistance; Hadrontherapy; Radioresistance; Rare gynecological tumors; Vulvar cancer.

Publication types

  • Review

MeSH terms

  • Bartholin's Glands / pathology*
  • Carcinoma, Adenoid Cystic / diagnosis
  • Carcinoma, Adenoid Cystic / drug therapy
  • Carcinoma, Adenoid Cystic / pathology*
  • Carcinoma, Adenoid Cystic / radiotherapy*
  • Female
  • Heavy Ion Radiotherapy / methods
  • Humans
  • Neoplasm Recurrence, Local
  • Prognosis
  • Rare Diseases / diagnosis
  • Rare Diseases / pathology
  • Rare Diseases / radiotherapy
  • Risk Factors
  • Vulvar Neoplasms / diagnosis
  • Vulvar Neoplasms / drug therapy
  • Vulvar Neoplasms / pathology*
  • Vulvar Neoplasms / radiotherapy*