Developmental Mutators and Early Onset Cancer

Front Pediatr. 2020 Apr 28:8:189. doi: 10.3389/fped.2020.00189. eCollection 2020.


A new hypothesis suggests that somatic genome remodeling during normal development can cause mutations that explain many early onset cancers in children and adults.

Keywords: cancer genetics and genomics; childhood cancer; developmental plasticity; mosaicism; prevention.