Telomere-led meiotic chromosome movements: recent update in structure and function

Nucleus. 2020 Jan 1;11(9):111-116. doi: 10.1080/19491034.2020.1769456.

Abstract

In S. cerevisiae prophase meiotic chromosomes move by forces generated in the cytoplasm and transduced to the telomere via a protein complex located in the nuclear membrane. We know that chromosome movements require actin cytoskeleton [13,31] and the proteins Ndj1, Mps3, and Csm4. Until recently, the identity of the protein connecting Ndj1-Mps3 with the cytoskeleton components was missing. It was also not known the identity of a cytoplasmic motor responsible for interacting with the actin cytoskeleton and a protein at the outer nuclear envelope. Our recent work [36] identified Mps2 as the protein connecting Ndj1-Mps3 with cytoskeleton components; Myo2 as the cytoplasmic motor that interacts with Mps2; and Cms4 as a regulator of Mps2 and Myo2 interaction and activities (Figure 1). Below we present a model for how Mps2, Csm4, and Myo2 promote chromosome movements by providing the primary connections joining telomeres to the actin cytoskeleton through the LINC complex.

Keywords: Csm4; LINC; Mps2; Myo2; rapid prophase movements (RPMs).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism
  • Chromosome Structures
  • Chromosomes, Fungal* / genetics
  • Chromosomes, Fungal* / metabolism
  • Meiosis* / genetics
  • Models, Molecular
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Telomere / genetics
  • Telomere / metabolism*

Substances

  • Saccharomyces cerevisiae Proteins