PTPmu-targeted nanoparticles label invasive pediatric and adult glioblastoma

Nanomedicine. 2020 Aug:28:102216. doi: 10.1016/j.nano.2020.102216. Epub 2020 May 13.


Poor prognosis for glioblastoma (GBM) is a consequence of the aggressive and infiltrative nature of gliomas where individual cells migrate away from the main tumor to distant sites, making complete surgical resection and treatment difficult. In this manuscript, we characterize an invasive pediatric glioma model and determine if nanoparticles linked to a peptide recognizing the GBM tumor biomarker PTPmu can specifically target both the main tumor and invasive cancer cells in adult and pediatric glioma models. Using both iron and lipid-based nanoparticles, we demonstrate by magnetic resonance imaging, optical imaging, histology, and iron quantification that PTPmu-targeted nanoparticles effectively label adult gliomas. Using PTPmu-targeted nanoparticles in a newly characterized orthotopic pediatric SJ-GBM2 model, we demonstrate individual tumor cell labeling both within the solid tumor margins and at invasive and dispersive sites.

Keywords: Glioblastoma; Glioma; Magnetic resonance contrast agent; Nanoparticle; PTPmu; Receptor type protein tyrosine phosphatase; Tumor targeting.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers, Tumor / metabolism
  • Female
  • Ferric Compounds / chemistry
  • Glioblastoma / diagnostic imaging*
  • Glioblastoma / metabolism
  • Glioma / diagnostic imaging
  • Glioma / metabolism
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Mice, Nude
  • Nanoparticles / chemistry*
  • Receptor-Like Protein Tyrosine Phosphatases, Class 2 / metabolism*


  • Biomarkers, Tumor
  • Ferric Compounds
  • ferric oxide
  • Receptor-Like Protein Tyrosine Phosphatases, Class 2