Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul;146(1):215-217.
doi: 10.1016/j.jaci.2020.05.006. Epub 2020 May 14.

Complement activation in patients with COVID-19: A novel therapeutic target

Massimo Cugno  1 , Pier Luigi Meroni  2 , Roberta Gualtierotti  3 , Samantha Griffini  3 , Elena Grovetti  3 , Adriana Torri  4 , Mauro Panigada  5 , Stefano Aliberti  6 , Francesco Blasi  6 , Francesco Tedesco  2 , Flora Peyvandi  3
Affiliations
Free PMC article

Complement activation in patients with COVID-19: A novel therapeutic target

Massimo Cugno et al. J Allergy Clin Immunol. 2020 Jul.
Free PMC article
No abstract available

PubMed Disclaimer

Figures

Fig 1
Fig 1
Plasma levels of complement terminal complex sC5b9 (upper panel) and activated C5a (lower panel) in 17 patients with COVID-19 requiring continuous positive airway pressure (moderate) and 14 patients with COVID-19 requiring mechanical ventilation (severe). The horizontal lines represent median values.
See this image and copyright information in PMC

Similar articles

  • Neutrophils and Contact Activation of Coagulation as Potential Drivers of COVID-19.
    Busch MH, Timmermans SAMEG, Nagy M, Visser M, Huckriede J, Aendekerk JP, de Vries F, Potjewijd J, Jallah B, Ysermans R, Oude Lashof AML, Breedveld PH, van de Poll MCG, van de Horst ICC, van Bussel BCT, Theunissen ROMFIH, Spronk HMH, Damoiseaux JGMC, Ten Cate H, Nicolaes GAF, Reutelingsperger CP, van Paassen P. Busch MH, et al. Circulation. 2020 Nov 3;142(18):1787-1790. doi: 10.1161/CIRCULATIONAHA.120.050656. Epub 2020 Sep 18. Circulation. 2020. PMID: 32946302 Free PMC article. No abstract available.
  • Type I IFN immunoprofiling in COVID-19 patients.
    Trouillet-Assant S, Viel S, Gaymard A, Pons S, Richard JC, Perret M, Villard M, Brengel-Pesce K, Lina B, Mezidi M, Bitker L, Belot A; COVID HCL Study group. Trouillet-Assant S, et al. J Allergy Clin Immunol. 2020 Jul;146(1):206-208.e2. doi: 10.1016/j.jaci.2020.04.029. Epub 2020 Apr 29. J Allergy Clin Immunol. 2020. PMID: 32360285 Free PMC article. No abstract available.
  • Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients.
    Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P, Dudman S, Ueland T, Andersen JT, Lund-Johansen F, Heggelund L, Dyrhol-Riise AM, Mollnes TE. Holter JC, et al. Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):25018-25025. doi: 10.1073/pnas.2010540117. Epub 2020 Sep 17. Proc Natl Acad Sci U S A. 2020. PMID: 32943538 Free PMC article.
  • The case of complement activation in COVID-19 multiorgan impact.
    Noris M, Benigni A, Remuzzi G. Noris M, et al. Kidney Int. 2020 Aug;98(2):314-322. doi: 10.1016/j.kint.2020.05.013. Epub 2020 May 24. Kidney Int. 2020. PMID: 32461141 Free PMC article. Review.
  • The complement system in COVID-19: friend and foe?
    Java A, Apicelli AJ, Liszewski MK, Coler-Reilly A, Atkinson JP, Kim AH, Kulkarni HS. Java A, et al. JCI Insight. 2020 Aug 6;5(15):e140711. doi: 10.1172/jci.insight.140711. JCI Insight. 2020. PMID: 32554923 Free PMC article. Review.
See all similar articles

Cited by

See all "Cited by" articles

References

    1. Guan W.J., Ni Z.Y., Hu Y., Liang W.H., Ou C.Q., He J.X. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708–1720. - PMC - PubMed
    1. Chen G., Wu D., Guo W., Cao Y., Huang D., Wang H. Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. J Clin Invest. 2020;130:2620–2629. - PMC - PubMed
    1. Riedl M., Fakhouri F., Le Quintrec M., Noone D.G., Jungraithmayr T.C., Fremeaux-Bacchi V. Spectrum of complement-mediated thrombotic microangiopathies: pathogenetic insights identifying novel treatment approaches. Semin Thromb Hemost. 2014;40:444–464. - PubMed
    1. Gralinski L.E., Sheahan T.P., Morrison T.E., Menachery V.D., Jensen K., Leist S.R. Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis. mBio. 2018;9 e01753-18. - PMC - PubMed
    1. Diao B, Wang C, Wang R, Feng Z, Tan Y, Wang H, et al. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection [published online ahead of print April 10, 2020]. medRxiv. 10.1101/2020.03.04.20031120. - DOI

Substances