Intrahepatic cholangiocarcinoma: pathogenesis, current staging, and radiological findings

Mohammed Saleh; Mayur Virarkar; Vlad Bura; Raul Valenzuela; Sanaz Javadi; Janio Szklaruk; Priya Bhosale

doi:10.1007/s00261-020-02559-7

Intrahepatic cholangiocarcinoma: pathogenesis, current staging, and radiological findings

Abdom Radiol (NY). 2020 Nov;45(11):3662-3680. doi: 10.1007/s00261-020-02559-7.

Authors

Mohammed Saleh¹, Mayur Virarkar², Vlad Bura³, Raul Valenzuela², Sanaz Javadi², Janio Szklaruk², Priya Bhosale²

Affiliations

¹ Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. mmsaleh@mdanderson.org.
² Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
³ Department of Radiology, County Clinical Emergency Hospital, 400006, Cluj-Napoca, Cluj, Romania.

PMID: 32417933
DOI: 10.1007/s00261-020-02559-7

Abstract

To this date, it is a major oncological challenge to optimally diagnose, stage, and manage intrahepatic cholangiocarcinoma (ICC). Imaging can not only diagnose and stage ICC, but it can also guide management. Hence, imaging is indispensable in the management of ICC. In this article, we review the pathology, epidemiology, genetics, clinical presentation, staging, pathology, radiology, and treatment of ICC.

Keywords: AJCC; CT; Cholangiocarcinoma; Intrahepatic; MRI; PET/CT.

Publication types

Review

MeSH terms

Bile Duct Neoplasms* / diagnostic imaging
Bile Duct Neoplasms* / pathology
Bile Ducts, Intrahepatic / diagnostic imaging
Bile Ducts, Intrahepatic / pathology
Cholangiocarcinoma* / diagnostic imaging
Cholangiocarcinoma* / pathology
Humans
Liver Neoplasms*
Neoplasm Staging