Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution!

Clin Immunol. 2020 Jul;216:108459. doi: 10.1016/j.clim.2020.108459. Epub 2020 May 11.

Abstract

The COVID-19 pandemic is one of the greatest infectious challenges in recent history. Presently, few treatment options exist and the availability of effective vaccines is at least one year away. There is an urgent need to find currently available, effective therapies in the treatment of patients with COVID-19 infection. In this review, we compare and contrast the use of intravenous immunoglobulin and hyperimmune globulin in the treatment of COVID-19 infection.

Keywords: COVID-19; Coronavirus; Hyperimmune globulin; Intravenous immunoglobulin; SARS-CoV-2.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity / drug effects
  • Angiotensin-Converting Enzyme 2
  • Antibody-Dependent Enhancement / drug effects
  • Betacoronavirus / drug effects*
  • Betacoronavirus / immunology
  • Betacoronavirus / pathogenicity
  • COVID-19
  • Coronavirus Infections / drug therapy*
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / immunology
  • Coronavirus Infections / therapy
  • Coronavirus Infections / virology
  • Cytokine Release Syndrome / etiology
  • Cytokine Release Syndrome / immunology
  • Cytokine Release Syndrome / pathology*
  • Cytokine Release Syndrome / prevention & control
  • Gene Expression
  • Humans
  • Immunity, Innate / drug effects
  • Immunization, Passive / adverse effects
  • Immunization, Passive / methods
  • Immunoglobulins, Intravenous / administration & dosage*
  • Immunoglobulins, Intravenous / adverse effects
  • Immunologic Factors / administration & dosage*
  • Immunologic Factors / adverse effects
  • Molecular Targeted Therapy
  • Pandemics*
  • Peptidyl-Dipeptidase A / genetics
  • Peptidyl-Dipeptidase A / immunology
  • Pneumonia, Viral / drug therapy*
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / virology
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus / genetics
  • Spike Glycoprotein, Coronavirus / immunology
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology
  • T-Lymphocytes / virology

Substances

  • Immunoglobulins, Intravenous
  • Immunologic Factors
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2

Supplementary concepts

  • COVID-19 serotherapy