Effect of Curcumin on Serum Urate in Asymptomatic Hyperuricemia: A Randomized Placebo-Controlled Trial

J Diet Suppl. 2021;18(3):248-260. doi: 10.1080/19390211.2020.1757798. Epub 2020 May 18.


Background/objective: Hyperuricemia leads to gout and renal complications and may increase cardiovascular risk. Curcumin inhibits xanthine oxidase and increases uricosuric activity and, as a result, decreases serum urate (SU). This randomized controlled trial aimed to determine the effects of curcumin versus placebo on SU in subjects with asymptomatic hyperuricemia (SU level ≥ 6 mg/dL in women or ≥ 7 mg/dL in men).

Methods: Thirty-nine subjects with persistent hyperuricemia were randomized to receive curcumin (500-mg capsules twice daily, 20 subjects) or placebo (19 subjects). Primary outcome was the difference between SU before and 8 weeks after randomization. Secondary outcomes were differences between urine uric acid (UUA) clearance, fasting plasma glucose (FPG), and lipid profiles before and 8 weeks after randomization and adverse events.

Results: Out of 39 subjects, there were no differences at baseline SU, UUA clearance, FPG, lipid profiles, and demographics between curcumin and placebo groups. After 8 weeks, SU was significantly decreased in both groups (6.9% in curcumin group, p = 0.002, and 5.0% in placebo group, p = 0.009). However, there was no difference in SU reduction between the two groups (p = 0.532). There were no differences in UUA, FPG, lipid profiles, or adverse events in either group at 8 weeks after randomization. The most common adverse event was diarrhea with no treatment required.

Conclusion: Curcumin was not superior to placebo in reducing serum urate and in increasing UUA clearance.

Keywords: Hyperuricemia; curcumin; serum urate; turmeric; urine uric acid clearance.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Curcumin* / therapeutic use
  • Female
  • Gout / prevention & control
  • Humans
  • Hyperuricemia* / drug therapy
  • Male
  • Treatment Outcome
  • Uric Acid / urine*


  • Uric Acid
  • Curcumin