ACE2 receptor expression in testes: implications in coronavirus disease 2019 pathogenesis†

Biol Reprod. 2020 Aug 21;103(3):449-451. doi: 10.1093/biolre/ioaa080.

Abstract

Expression of angiotensin-converting enzyme 2, receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is high in the testes, therefore SARS-CoV-2 infection and its association with male reproductive health should be investigated in male coronavirus disease 2019 patients.

Keywords: ACE2; Leydig cells; SARS-CoV-2; cytokines and infertility; testis.

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus*
  • COVID-19
  • Coronavirus Infections / etiology*
  • Coronavirus Infections / metabolism*
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Male
  • Pandemics
  • Peptidyl-Dipeptidase A / genetics
  • Peptidyl-Dipeptidase A / metabolism*
  • Pneumonia, Viral / etiology*
  • Pneumonia, Viral / metabolism*
  • SARS-CoV-2
  • Testis / metabolism*

Substances

  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2