Intrinsic functional architecture of the human speech processing network

Daniel A Abrams; John Kochalka; Sayuli Bhide; Srikanth Ryali; Vinod Menon

doi:10.1016/j.cortex.2020.03.013

Intrinsic functional architecture of the human speech processing network

Cortex. 2020 Aug:129:41-56. doi: 10.1016/j.cortex.2020.03.013. Epub 2020 Apr 21.

Authors

Daniel A Abrams¹, John Kochalka², Sayuli Bhide², Srikanth Ryali², Vinod Menon³

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: daa@stanford.edu.
² Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
³ Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; Program in Neuroscience, Stanford University School of Medicine, Stanford, CA, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: menon@stanford.edu.

PMID: 32428761
DOI: 10.1016/j.cortex.2020.03.013

Abstract

Speech engages distributed temporo-fronto-parietal brain regions, however a comprehensive understanding of its intrinsic functional network architecture is lacking. Here we investigate the human speech processing network using the largest sample to date, high temporal resolution resting-state fMRI data, network stability analysis, and theoretically informed models. Network consensus analysis revealed three stable functional modules encompassing: (1) superior temporal plane (STP) and Area Spt, (2) superior temporal sulcus (STS) + ventral frontoparietal cortex, and (3) dorsal frontoparietal cortex. The STS + ventral frontoparietal cortex module showed the highest participation coefficient, and a hub-like organization linking STP with frontoparietal cortical nodes. Node-wise analysis revealed key connectivity features underlying this modular architecture, including a leftward asymmetric connectivity profile, and differential connectivity of STS and STP, with frontoparietal cortex. Our findings, replicated across cohorts, reveal a tripartite functional network architecture supporting speech processing and provide a novel template for future studies.

Keywords: Angular gyrus; Auditory cortex; Inferior frontal gyrus; Speech; Superior temporal sulcus.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Brain Mapping*
Humans
Magnetic Resonance Imaging
Parietal Lobe
Speech*
Temporal Lobe

Abstract

Publication types

MeSH terms

Grants and funding