Genetic factors and socioeconomic status (SES) inequalities play a large role in educational attainment, and both have been associated with variations in brain structure and cognition. However, genetics and SES are correlated, and no prior study has assessed their neural associations independently. Here we used a polygenic score for educational attainment (EduYears-PGS), as well as SES, in a longitudinal study of 551 adolescents to tease apart genetic and environmental associations with brain development and cognition. Subjects received a structural MRI scan at ages 14 and 19. At both time points, they performed three working memory (WM) tasks. SES and EduYears-PGS were correlated (r = 0.27) and had both common and independent associations with brain structure and cognition. Specifically, lower SES was related to less total cortical surface area and lower WM. EduYears-PGS was also related to total cortical surface area, but in addition had a regional association with surface area in the right parietal lobe, a region related to nonverbal cognitive functions, including mathematics, spatial cognition, and WM. SES, but not EduYears-PGS, was related to a change in total cortical surface area from age 14 to 19. This study demonstrates a regional association of EduYears-PGS and the independent prediction of SES with cognitive function and brain development. It suggests that the SES inequalities, in particular parental education, are related to global aspects of cortical development, and exert a persistent influence on brain development during adolescence.
Keywords: development; polygenic scores; socioeconomic status; structural MRI; working memory.
Conflict of interest statement
The authors declare no competing interest.
Longitudinally Mapping Childhood Socioeconomic Status Associations with Cortical and Subcortical Morphology.J Neurosci. 2019 Feb 20;39(8):1365-1373. doi: 10.1523/JNEUROSCI.1808-18.2018. Epub 2018 Dec 26. J Neurosci. 2019. PMID: 30587541 Free PMC article.
Educational attainment polygenic scores are associated with cortical total surface area and regions important for language and memory.Neuroimage. 2020 May 15;212:116691. doi: 10.1016/j.neuroimage.2020.116691. Epub 2020 Feb 29. Neuroimage. 2020. PMID: 32126298
The moderating role of SES on genetic differences in educational achievement in the Netherlands.NPJ Sci Learn. 2019 Sep 3;4:13. doi: 10.1038/s41539-019-0052-2. eCollection 2019. NPJ Sci Learn. 2019. PMID: 31508241 Free PMC article.
The pathways from parental and neighbourhood socioeconomic status to adolescent educational attainment: An examination of the role of cognitive ability, teacher assessment, and educational expectations.PLoS One. 2019 May 22;14(5):e0216803. doi: 10.1371/journal.pone.0216803. eCollection 2019. PLoS One. 2019. PMID: 31116770 Free PMC article. Clinical Trial.
Associations among family socioeconomic status, EEG power at birth, and cognitive skills during infancy.Version 2. Dev Cogn Neurosci. 2016 Jun;19:144-51. doi: 10.1016/j.dcn.2016.03.004. Epub 2016 Mar 14. Dev Cogn Neurosci. 2016. PMID: 27003830 Free PMC article. Review.