Longitudinal study on nerve ultrasound and corneal confocal microscopy in NF155 paranodopathy

Ann Clin Transl Neurol. 2020 Jun;7(6):1061-1068. doi: 10.1002/acn3.51061. Epub 2020 May 20.


We report the case of a 27-year-old patient with subacute anti-neurofascin-155 neuropathy with bifacial palsy, who showed excellent response to rituximab. We provide longitudinal data of established clinical scores, nerve conduction studies, antibody titers, and novel imaging methods (nerve ultrasonography and corneal confocal microscopy). Clinical and electrophysiological improvement followed the reduction of serum antibody titer and correlated with a reduction of corneal inflammatory cellular infiltrates whereas the increase in the cross-sectional area of the peripheral nerves remained 12 months after first manifestation. Our findings suggest that novel techniques provide useful follow-up parameters in paranodopathies.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cell Adhesion Molecules / immunology*
  • Cornea / diagnostic imaging*
  • Humans
  • Longitudinal Studies
  • Male
  • Microscopy, Confocal
  • Nerve Growth Factors / immunology*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnostic imaging*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / immunology
  • Spinal Nerves / diagnostic imaging*
  • Ultrasonography


  • Cell Adhesion Molecules
  • NFASC protein, human
  • Nerve Growth Factors