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. 2020 Jun 16;323(23):2427-2429.
doi: 10.1001/jama.2020.8707.

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

Supinda Bunyavanich  1 , Anh Do  2 , Alfin Vicencio  1
Affiliations

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

Supinda Bunyavanich et al. JAMA. .

Abstract

This study compares angiotensin-converting enzyme 2 (ACE2) gene expression, which has been associated with SARS-CoV-2 cell entry, in the nasal epithelium of children vs adults.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Vicencio reported being an investor in Filament Biosolutions. No other disclosures were reported.

Figures

Figure.
Figure.. Nasal Gene Expression of ACE2 in Different Age Groups
Data are means (data points) and 95% confidence intervals (error bars) for angiotensin-converting enzyme 2 (ACE2) gene expression in younger children (aged <10 years), older children (aged 10-17 years), young adults (aged 18-24 years), and adults (aged ≥25 years). Gene counts are shown as logarithmic (log2) counts per million. P values are from linear regression modeling in which ACE2 gene expression in log2 counts per million was the dependent variable and age group was the independent variable.
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