Urinary Reflux Into the Prostate Gland and Seminal Vesicles: A Potential Pitfall in 18F-FDG and 68Ga-PSMA PET/CT

Clin Nucl Med. 2020 Jul;45(7):536-537. doi: 10.1097/RLU.0000000000003069.


A 64-year-old man with lung cancer underwent F-FDG PET/CT for restaging, which demonstrated intense F-FDG uptake in the right lobe of prostate gland and seminal vesicles, indicating a potential prostate cancer. In Ga-PSMA PET/CT, intense uptake in the right lobe of prostate gland and seminal vesicles was also observed but decreased in postmictional delayed images. Magnetic resonance imaging showed high signal intensity of urine in the same areas of uptakes. F-FDG and Ga-PSMA PET/CT findings in the prostate gland and seminal vesicles were considered to be a result of urinary reflux possibly because of the patient's previous transurethral resection.

Publication types

  • Case Reports

MeSH terms

  • Artifacts
  • Fluorodeoxyglucose F18*
  • Humans
  • Male
  • Membrane Glycoproteins*
  • Middle Aged
  • Organometallic Compounds*
  • Positron Emission Tomography Computed Tomography*
  • Prostate / diagnostic imaging*
  • Prostate / metabolism
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / urine
  • Seminal Vesicles / diagnostic imaging*
  • Seminal Vesicles / metabolism
  • Urine*


  • Membrane Glycoproteins
  • Organometallic Compounds
  • gallium 68 PSMA-11
  • Fluorodeoxyglucose F18