Pig-specific RNA editing during early embryo development revealed by genome-wide comparisons

FEBS Open Bio. 2020 Jul;10(7):1389-1402. doi: 10.1002/2211-5463.12900. Epub 2020 Jun 25.


Posttranscriptional modification of mRNA sequences through RNA editing can increase transcriptome and proteome diversity in eukaryotes. Studies of fetal and adult tissues showed that adenosine-to-inosine RNA editing plays a crucial role in early human development, but there is a lack of global understanding of dynamic RNA editing during mammalian early embryonic development. Therefore, here we used RNA sequencing data from human, pig and mouse during early embryonic development to detect edited genes that may regulate stem cell pluripotency. We observed that although most of the RNA editing sites are located in intergenic, intron and UTR, a few editing sites are in coding regions and may result in nonsynonymous amino acid changes. Some editing sites are predicted to change the structure of a protein. We also report that HNF1A, TBX3, ACLY, ECI1 and ERDR1 are related to embryonic development and cell division.

Keywords: ECI1; HNF1A; HOX family; RNA editing; early embryo development; pig.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosomes / genetics
  • Embryonic Development
  • Humans
  • Mice
  • RNA Editing*
  • RNA, Messenger / genetics*
  • RNA-Seq
  • Swine


  • RNA, Messenger