Neutrophils Create an ImpeNETrable Shield between Tumor and Cytotoxic Immune Cells

Immunity. 2020 May 19;52(5):729-731. doi: 10.1016/j.immuni.2020.04.009.


Neutrophil extracellular traps (NETs) can promote tumor growth and metastases, but whether NETs impact the tumor immune microenvironment remains underexplored. In this issue of Immunity, Teijeira et al. discover that NETs shield tumor cells from cytotoxic immune cells, resulting in impaired tumor clearance.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Chemokines
  • Extracellular Traps*
  • Humans
  • Neoplasms*
  • Neutrophils
  • Tumor Microenvironment


  • Chemokines