CRNDE: an oncogenic long non-coding RNA in cancers

Ya Lu; Huanhuan Sha; Xun Sun; Yuan Zhang; Yang Wu; Junying Zhang; Hui Zhang; Jianzhong Wu; Jifeng Feng

doi:10.1186/s12935-020-01246-3

CRNDE: an oncogenic long non-coding RNA in cancers

Cancer Cell Int. 2020 May 12:20:162. doi: 10.1186/s12935-020-01246-3. eCollection 2020.

Authors

Ya Lu^#^{1

2}, Huanhuan Sha^#^{1

2}, Xun Sun^#^{1

2}, Yuan Zhang^#¹, Yang Wu¹, Junying Zhang¹, Hui Zhang^{1

2}, Jianzhong Wu¹, Jifeng Feng¹

Affiliations

¹ 1Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Baiziting42, 210009 Nanjing, China.
² 2The Forth Clinical School of Nanjing Medical University, Nanjing, China.

^# Contributed equally.

Abstract

Colorectal neoplasia differentially expressed (CRNDE) is a long non-coding RNA which has been proved upregulated in various cancers. Meanwhile, CRNDE has been demonstrated to be involved in multiple biological processes of different cancers according to previous study. Moreover, recent studies suggested CRNDE might be a potential diagnostic biomarker and prognostic predictor due to its high sensitivity and specificity in cancer tissues and plasma. In this review, we summarize the biological function of CRNDE and the relevant mechanisms in cancers to establish a molecular basis for the clinical use of CRNDE in the future.

Keywords: Biomarker; CRNDE; Cancer; lncRNA.

Publication types

Review