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. 2020 May 21;ciaa623.
doi: 10.1093/cid/ciaa623. Online ahead of print.

Connecting Hydroxychloroquine in Vitro Antiviral Activity to in Vivo Concentration for Prediction of Antiviral Effect: A Critical Step in Treating COVID-19 Patients

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Connecting Hydroxychloroquine in Vitro Antiviral Activity to in Vivo Concentration for Prediction of Antiviral Effect: A Critical Step in Treating COVID-19 Patients

Jianghong Fan et al. Clin Infect Dis. .

Abstract

Translation of in vitro antiviral activity to the in vivo setting is crucial to identify potentially effective dosing regimens of hydroxychloroquine. In vitro EC50/EC90 values for hydroxychloroquine should be compared to the in vivo free extracellular tissue concentration, which is similar to the free plasma hydroxychloroquine concentration.

Keywords: COVID-19; Hydroxychloroquine; SARS-CoV-2; antiviral activity.

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