Human Intestinal Defensin 5 Inhibits SARS-CoV-2 Invasion by Cloaking ACE2

Cheng Wang; Shaobo Wang; Daixi Li; Dong-Qing Wei; Jinghong Zhao; Junping Wang

doi:10.1053/j.gastro.2020.05.015

Human Intestinal Defensin 5 Inhibits SARS-CoV-2 Invasion by Cloaking ACE2

Gastroenterology. 2020 Sep;159(3):1145-1147.e4. doi: 10.1053/j.gastro.2020.05.015. Epub 2020 May 11.

Authors

Cheng Wang¹, Shaobo Wang², Daixi Li³, Dong-Qing Wei⁴, Jinghong Zhao⁵, Junping Wang⁶

Affiliations

¹ State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
² Department of Nephrology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
³ Institute of Biothermal Science and Technology, University of Shanghai for Science and Technology, Shanghai, China.
⁴ State Key Laboratory of Microbial Metabolism, Shanghai-Islamabad-Belgrade Joint Innovation Center on Antibacterial Resistances, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, Ministry of Education and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China; Peng Cheng Laboratory, Shenzhen, China. Electronic address: dqwei@sjtu.edu.cn.
⁵ Department of Nephrology, Xinqiao Hospital, Third Military Medical University, Chongqing, China. Electronic address: zhaojh@tmmu.edu.cn.
⁶ State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China. Electronic address: wangjunping@tmmu.edu.cn.

No abstract available

Keywords: ACE2, angiotensin-converting enzyme-2; COVID-19, coronavirus disease 2019; HD5, Human Defensin-5; LBD, ligand-binding domain; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiotensin-Converting Enzyme 2
Betacoronavirus / physiology*
COVID-19
Cell Culture Techniques
Coronavirus Infections / metabolism
Coronavirus Infections / pathology
Coronavirus Infections / virology*
Enterocytes / metabolism
Enterocytes / virology*
Humans
Microscopy, Interference
Pandemics
Paneth Cells / metabolism
Paneth Cells / virology*
Peptidyl-Dipeptidase A / physiology*
Pneumonia, Viral / metabolism
Pneumonia, Viral / pathology
Pneumonia, Viral / virology*
SARS-CoV-2
Virus Attachment
alpha-Defensins / physiology*

Substances

DEFA5 protein, human
alpha-Defensins
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2