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. 2020 May 8;S0085-2538(20)30527-5.
doi: 10.1016/j.kint.2020.05.001. Online ahead of print.

Autophagy Inhibition by Chloroquine and Hydroxychloroquine Could Adversely Affect Acute Kidney Injury and Other Organ Injury in Critically Ill Patients With COVID-19

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Free PMC article

Autophagy Inhibition by Chloroquine and Hydroxychloroquine Could Adversely Affect Acute Kidney Injury and Other Organ Injury in Critically Ill Patients With COVID-19

Charles L Edelstein et al. Kidney Int. .
Free PMC article

Figures

Figure 1
Figure 1
Chloroquine could be a double edged sword. Chloroquine may slow virus infection and replication early, but may later potentiate tissue damage and worsen acute organ injury by inhibiting autophagy.

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References

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