Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May 11;106017.
doi: 10.1016/j.ijantimicag.2020.106017. Online ahead of print.

Neutrophil-to-lymphocyte Ratio and Clinical Outcome in COVID-19: A Report From the Italian Front Line

Free PMC article

Neutrophil-to-lymphocyte Ratio and Clinical Outcome in COVID-19: A Report From the Italian Front Line

Arturo Ciccullo et al. Int J Antimicrob Agents. .
Free PMC article


Clinicians are looking for a reliable prognostic marker for patients with COVID-19.In our cohort, clinical improvement was predicted by younger age and a NLR below 3.Transfer to ICU was instead predicted by a NLR over 4 (p=0.046).NLR is a fast, widely available and relatively inexpensive assessment.NLR may be a useful tool in the early screening of patients with COVID-19.

Similar articles

See all similar articles


    1. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–1062. doi: 10.1016/S0140-6736(20)30566-3. Errata in: Lancet 2020;395:1038; Lancet 2020;395:1038. - DOI - PMC - PubMed
    1. Templeton AJ, McNamara MG, Šeruga B, Vera-Badillo FE, Aneja P, Ocaña A. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst. 2014;106 doi: 10.1093/jnci/dju124. dju124. - DOI
    1. Società Italiana di Malattie Infettive e Tropicali (SIMIT). Vademecum per la cura delle persone con malattia da COVID-19. Edizione 2.0, 13 marzo 2020 [Handbook for the treatment of people with COVID-19 disease. Edition 2.0, 13 March 2020].[accessed 27 March 2020].
    1. Qu R, Ling Y, Zhang YH, Wei LY, Chen X, Li XM. Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19. J Med Virol. 2020 Mar 17 doi: 10.1002/jmv.25767. [Epub ahead of print] - DOI
    1. Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. 2020 Mar 12 doi: 10.1093/cid/ciaa248. [Epub ahead of print] - DOI