Summary of Updated Recommendations for Primary Prevention of Cardiovascular Disease in Women: JACC State-of-the-Art Review

J Am Coll Cardiol. 2020 May 26;75(20):2602-2618. doi: 10.1016/j.jacc.2020.03.060.


Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality for women in the United States and worldwide. There has been no American College of Cardiology (ACC)/American Heart Association guideline update specifically for the prevention of CVD in women since 2011. Since then, the body of sex-specific data has grown, in addition to updated hypertension, cholesterol, diabetes, atrial fibrillation, and primary prevention guidelines. The ACC CVD in Women Committee undertook a review of the recent guidelines and major studies to summarize recommendations pertinent to women. In this update, the authors address special topics, particularly the risk factors and treatments that have led to some controversies and confusion. Specifically, sex-related risk factors, hypertension, diabetes, hyperlipidemia, anticoagulation for atrial fibrillation, use of aspirin, perimenopausal hormone therapy, and psychosocial issues are highlighted.

Keywords: adverse pregnancy outcomes; aspirin; atrial fibrillation; cardiovascular disease; gestational diabetes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Abortion, Spontaneous / physiopathology
  • Autoimmune Diseases
  • Cardiology / methods*
  • Cardiology / standards*
  • Cardiovascular Diseases / prevention & control*
  • Diabetes Mellitus, Type 2 / complications
  • Female
  • Fetal Growth Retardation / physiopathology
  • Humans
  • Hypertension / complications
  • Male
  • Menopause, Premature
  • Polycystic Ovary Syndrome / complications
  • Practice Guidelines as Topic*
  • Pregnancy
  • Pregnancy Complications, Cardiovascular
  • Primary Prevention / standards*
  • Risk Factors
  • Sex Factors
  • Societies, Medical
  • Stroke / prevention & control
  • United States
  • Women's Health