Neurodevelopmental Factors in Schizophrenia

Hanna Jaaro-Peled; Akira Sawa

doi:10.1016/j.psc.2020.02.010

Neurodevelopmental Factors in Schizophrenia

Psychiatr Clin North Am. 2020 Jun;43(2):263-274. doi: 10.1016/j.psc.2020.02.010. Epub 2020 Apr 22.

Authors

Hanna Jaaro-Peled¹, Akira Sawa²

Affiliations

¹ Department of Psychiatry, Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins Hospital, Meyer 3-166, 600 North Wolfe Street, Baltimore, MD, 21287, USA. Electronic address: hjaarop1@jhmi.edu.
² Department of Psychiatry, Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins Hospital, Meyer 3-166, 600 North Wolfe Street, Baltimore, MD, 21287, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins Hospital, Meyer 3-166, 600 North Wolfe Street, Baltimore, MD 21287, USA; Department of Mental Health, Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins Hospital, Meyer 3-166, 600 North Wolfe Street, Baltimore, MD 21287, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins Hospital, Meyer 3-166, 600 North Wolfe Street, Baltimore, MD 21287, USA; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins Hospital, Meyer 3-166, 600 North Wolfe Street, Baltimore, MD 21287, USA.

PMID: 32439021
DOI: 10.1016/j.psc.2020.02.010

Abstract

The onset of schizophrenia is usually in late adolescence or early adulthood. However, accumulating evidence has suggested that the disease condition is an outcome of gene-environment interactions that act in neural development during early life and adolescence. Some children who later develop schizophrenia have early developmental and educational and social challenges. Some patients with schizophrenia have an abundance of nonspecific neurologic soft signs and minor physical anomalies. Adolescence is a sensitive period of increased neuronal plasticity. It is important to consider early detection and intervention from the prodromal stage to early disease to prevent its devastating long-term consequences.

Keywords: Early intervention; Gene-environment; Neurodevelopment; Schizophrenia.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adolescent
Early Diagnosis
Humans
Prodromal Symptoms
Risk Factors
Schizophrenia / diagnosis*
Schizophrenia / physiopathology
Schizophrenic Psychology*