Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Filters applied. Clear all
. 2020 May 20.
doi: 10.1097/QAD.0000000000002580. Online ahead of print.

High Levels of Resistance to Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Newly-Diagnosed Antiretroviral Treatment Naive Children in sub-Saharan Africa

Affiliations

High Levels of Resistance to Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Newly-Diagnosed Antiretroviral Treatment Naive Children in sub-Saharan Africa

Seth C Inzaule et al. AIDS. .

Abstract

: Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.

Similar articles

See all similar articles

LinkOut - more resources

Feedback