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. 2020 May 22;jiaa270.
doi: 10.1093/infdis/jiaa270. Online ahead of print.

Kinetics of Plasma HIV Rebound in the Era of Modern Antiretroviral Therapy

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Kinetics of Plasma HIV Rebound in the Era of Modern Antiretroviral Therapy

Michael C Sneller et al. J Infect Dis. .

Abstract

Historical data regarding time to viral rebound following analytical treatment interruption (ATI) have been used to determine therapeutic efficacy in HIV cure trials; however, such data were collected from studies conducted a decade or more ago and included participants receiving older antiretroviral therapy (ART) regimens with infrequent virologic monitoring. We conducted a study of 22 HIV-infected participants receiving "modern" ART to determine the kinetics of plasma viral rebound following ATI. Our data suggest that "modern" ART does not alter kinetics of viral rebound when compared to previous regimens and that immunologic interventions may be necessary to achieve ART-free virologic remission.

Keywords: Human immunodeficiency virus; analytical treatment interruption; antiretroviral therapy.

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