An observational study of the lung clearance index throughout childhood in cystic fibrosis: early years matter

Gwyneth Davies; Sanja Stanojevic; Emma Raywood; Julie A Duncan; Janet Stocks; Sooky Lum; Andrew Bush; Laura Viviani; Angie Wade; Alistair Calder; Catherine M Owens; Christophe Goubau; Siobhán B Carr; Cara J Bossley; Caroline Pao; Paul Aurora; London Cystic Fibrosis Collaboration

doi:10.1183/13993003.00006-2020

An observational study of the lung clearance index throughout childhood in cystic fibrosis: early years matter

Eur Respir J. 2020 Oct 1;56(4):2000006. doi: 10.1183/13993003.00006-2020. Print 2020 Oct.

Authors

Gwyneth Davies^{1

2

3}, Sanja Stanojevic^{4

3}, Emma Raywood⁵, Julie A Duncan⁵, Janet Stocks⁵, Sooky Lum⁵, Andrew Bush⁶, Laura Viviani⁵, Angie Wade⁷, Alistair Calder⁸, Catherine M Owens⁸, Christophe Goubau⁵, Siobhán B Carr⁶, Cara J Bossley⁹, Caroline Pao¹⁰, Paul Aurora^{5

2}; London Cystic Fibrosis Collaboration

Affiliations

¹ Infection, Immunity and Inflammation Research and Teaching Dept, UCL Great Ormond Street Institute of Child Health (UCL GOS ICH), London, UK gwyneth.davies@ucl.ac.uk.
² Dept of Respiratory Medicine, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
³ Joint first authors.
⁴ Translational Medicine, SickKids Research Institute, Toronto, ON, Canada.
⁵ Infection, Immunity and Inflammation Research and Teaching Dept, UCL Great Ormond Street Institute of Child Health (UCL GOS ICH), London, UK.
⁶ Dept of Paediatric Respiratory Medicine, Imperial College and Royal Brompton and Harefield Hospital NHS Foundation Trust, London, UK.
⁷ Clinical Epidemiology, Nutrition and Biostatistics Section, UCL GOS ICH, London, UK.
⁸ Dept of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
⁹ Dept of Paediatric Respiratory Medicine, Kings College Hospital, London, UK.
¹⁰ Dept of Paediatric Respiratory Medicine, Royal London Hospital, London, UK.

Abstract

Lung clearance index (LCI) in the early years was associated with LCI during adolescence in children with cystic fibrosis. Pre-school LCI may help to identify children in whom treatment could be intensified. https://bit.ly/2yKyMbM

Publication types

Letter
Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Child
Cystic Fibrosis*
Humans
Lung / diagnostic imaging
Respiratory Function Tests