Effectiveness of a novel hydrolyzed collagen formulation in treating patients with symptomatic knee osteoarthritis: a multicentric retrospective clinical study

Int Orthop. 2021 Feb;45(2):375-380. doi: 10.1007/s00264-020-04616-8. Epub 2020 May 23.


Purpose: Knee osteoarthritis (OA) is a musculoskeletal disorder that may have a heavy impact on the patients' quality of life. Intra-articular collagen injection may be a safe adjuvant. Recently, CHondroGrid (CG), a hydrolyzed (< 3 kDa) bovine collagen injectable formulation, has been placed on the market. The aim of this study was to investigate the safety and performance profile of CG.

Methods: Patients affected by Kellgren Lawrence grade 1 to 4 knee OA and BMI < 30 were treated by administering three CG injections of 2 ml (4 mg) each (at 15 days and 45 days from the first one, respectively) and were followed up for six months after the last administration. Clinical records were retrospectively assessed to compare VAS, Lequesne and WOMAC total, pain, stiffness, and physical function scores collected at baseline and 15, 45, and 225 days after the first injection.

Results: At the last follow-up, 70 patients (37 men and 33 women, aged 57.1 ± 14.5 years) treated with CG showed a 50% reduction in their median Lequesne score, a 50% reduction in their VAS score at rest and moving, and a ≥ 50% reduction for all other scores under consideration.

Conclusions: CG may be a safe and effective adjuvant in the treatment of symptomatic knee OA.

Keywords: CHondroGrid; Intra-articular injection; Knee osteoarthritis; Non-pharmacological therapy.

MeSH terms

  • Adult
  • Aged
  • Animals
  • Cattle
  • Female
  • Humans
  • Hyaluronic Acid / therapeutic use
  • Injections, Intra-Articular
  • Male
  • Middle Aged
  • Osteoarthritis, Knee* / drug therapy
  • Pain Measurement
  • Quality of Life
  • Retrospective Studies
  • Treatment Outcome


  • Hyaluronic Acid