Sufficient increment of sulfonylurea without reintroduction of insulin ameliorates pubertal deterioration of glycaemic control in KCNJ11 neonatal diabetes treated with long-term sulfonylurea

Diabetologia. 2020 Aug;63(8):1659-1661. doi: 10.1007/s00125-020-05182-9. Epub 2020 May 24.

Authors

Shigeru Suzuki¹, Tokuo Mukai², Takahide Kokumai³, Akiko Furuya³, Yusuke Tanahashi³, Hiroshi Azuma³

Affiliations

¹ Department of Pediatrics, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan. shige5p@asahikawa-med.ac.jp.
² Department of Pediatrics, Japanese Red Cross Asahikawa Hospital, Asahikawa, Hokkaido, Japan.
³ Department of Pediatrics, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.

PMID: 32448915
DOI: 10.1007/s00125-020-05182-9

No abstract available

Keywords: Glibenclamide; Glycaemic control; KCNJ11; Neonatal diabetes mellitus; Puberty; Sulfonylurea.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Diabetes Mellitus / blood*
Diabetes Mellitus / drug therapy*
Glycemic Control / methods
Humans
Hypoglycemic Agents / therapeutic use*
Infant
Male
Mutation / genetics
Potassium Channels, Inwardly Rectifying / genetics
Sulfonylurea Compounds / therapeutic use*

Substances

Hypoglycemic Agents
Kir6.2 channel
Potassium Channels, Inwardly Rectifying
Sulfonylurea Compounds

Grants and funding

JP18K07867/JSPS KAKENHI/International