Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain

Endocrinology. 2020 Aug 1;161(8):bqaa083. doi: 10.1210/endocr/bqaa083.


Nuclear receptor coactivators (NCOAs) and corepressors (NCORs) bind to nuclear hormone receptors in a ligand-dependent manner and mediate the transcriptional activation or repression of the downstream target genes in response to hormones, metabolites, xenobiotics, and drugs. NCOAs and NCORs are widely expressed in the mammalian brain. Studies using genetic animal models started to reveal pivotal roles of NCOAs/NCORs in the brain in regulating hormonal signaling, sexual behaviors, consummatory behaviors, exploratory and locomotor behaviors, moods, learning, and memory. Genetic variants of NCOAs or NCORs have begun to emerge from human patients with obesity, hormonal disruption, intellectual disability, or autism spectrum disorders. Here we review recent studies that shed light on the function of NCOAs and NCORs in the central nervous system.

Keywords: behavior; brain; neuroendocrine; nuclear receptor corepressor (NCOR); steroid receptor coactivator (SRC).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Behavior / physiology
  • Brain / metabolism*
  • Brain / physiology
  • Co-Repressor Proteins / metabolism
  • Co-Repressor Proteins / physiology*
  • Humans
  • Neurosecretory Systems / physiology
  • Nuclear Receptor Coactivators / metabolism
  • Nuclear Receptor Coactivators / physiology*
  • Transcriptional Activation


  • Co-Repressor Proteins
  • Nuclear Receptor Coactivators