Beyond Stiffness: Collagen Signaling in Pancreatic Cancer and Pancreas Regeneration

Huocong Huang; Rolf A Brekken

doi:10.1016/j.ajpath.2020.05.005

Beyond Stiffness: Collagen Signaling in Pancreatic Cancer and Pancreas Regeneration

Am J Pathol. 2020 Aug;190(8):1622-1624. doi: 10.1016/j.ajpath.2020.05.005. Epub 2020 May 22.

Authors

Huocong Huang¹, Rolf A Brekken²

Affiliations

¹ Division of Surgical Oncology, Department of Surgery, and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas.
² Division of Surgical Oncology, Department of Surgery, and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: rolf.brekken@utsouthwestern.edu.

Abstract

This commentary highlights the article by Ruggeri et al that reports the importance of discoidin domain receptor 1 in tissue homeostasis in pancreatic injury and pancreatic ductal adenocarcinoma pathogenesis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Carcinoma, Pancreatic Ductal*
Collagen
Discoidin Domain Receptor 1
Homeostasis
Humans
Pancreatic Neoplasms*
Regeneration

Substances

Collagen
DDR1 protein, human
Discoidin Domain Receptor 1

Grants and funding

U54 CA210181/CA/NCI NIH HHS/United States