The role of advanced glycation end products in human infertility

Life Sci. 2020 Aug 15:255:117830. doi: 10.1016/j.lfs.2020.117830. Epub 2020 May 22.


Advanced glycation end products (AGEs) are heterogeneous products of the non-enzymatic interaction between proteins and reducing sugars. Numerous studies have shown that AGEs are associated with senescence, diabetes, vascular disease, aging and kidney disease. Infertility has been affected approximately 10 to15% of couples of reproductive ages. AGEs accumulation has been shown to play a crucial role in pathogenesis of infertility-related diseases. The present review provides the generation process, mechanism and pathological significance of AGEs and the novel treatment targeting AGEs for infertility.

Keywords: Advanced glycation end products (AGEs); DNA damage; Infertility; Ovulatory dysfunction; Oxidative stress.

Publication types

  • Review

MeSH terms

  • Animals
  • Female
  • Glycation End Products, Advanced / metabolism*
  • Humans
  • Infertility / epidemiology
  • Infertility / physiopathology*
  • Male


  • Glycation End Products, Advanced