Same same but different - Antiviral factors interfering with the infectivity of HIV particles

Microbes Infect. 2020 Oct;22(9):416-422. doi: 10.1016/j.micinf.2020.05.009. Epub 2020 May 22.

Abstract

Human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS). Novel strategies to combat this pandemic include the discovery of cellular proteins targeting distinct steps of the HIV replication cycle. Here, we summarize our current knowledge on antiviral proteins interfering with the infectivity of released HIV particles.

Keywords: Antiviral proteins; HIV; Infectivity; Innate immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • APOBEC Deaminases
  • Acquired Immunodeficiency Syndrome
  • Antigens, Differentiation
  • Antigens, Neoplasm
  • Antiviral Agents / pharmacology*
  • Biomarkers, Tumor
  • Extracellular Matrix Proteins
  • HIV Infections / drug therapy*
  • HIV-1 / drug effects*
  • Humans
  • Immunity, Innate
  • Membrane Glycoproteins
  • Peptides / pharmacology
  • Proteins / pharmacology
  • Ubiquitin-Protein Ligases
  • Virus Replication

Substances

  • APOBEC Deaminases
  • Antigens, Differentiation
  • Antigens, Neoplasm
  • Antiviral Agents
  • Biomarkers, Tumor
  • Membrane Glycoproteins
  • Peptides
  • Proteins
  • Ubiquitin-Protein Ligases
  • LGALS3BP protein, human
  • Extracellular Matrix Proteins