Recurrent Aphthous Stomatitis

Actas Dermosifiliogr (Engl Ed). 2020 Jul-Aug;111(6):471-480. doi: 10.1016/ Epub 2020 May 22.
[Article in English, Spanish]


Recurrent aphthous stomatitis is a chronic inflammatory disease of the oral mucosa. It is characterized by painful mouth ulcers that cannot be explained by an underlying disease. Recurrent oral mucosal ulcers require a proper differential diagnosis to rule out other possible causes before recurrent aphthous stomatitis is diagnosed. The condition is common, with prevalence rates ranging from 5 to 60% in different series. Its pathogenesis is unknown, but multiple factors are considered to play a part. There are no standardized treatments for this condition and none of the treatments are curative. The goal of any treatment should be to alleviate pain, reduce the duration of ulcers, and prevent recurrence.

Keywords: Afta; Aftosis oral recidivante; Aphthae; Mucosa oral; Oral mucosa; Oral ulcers; Periodic fever syndrome; Recurrent aphthous stomatitis; Síndrome periódico; Úlceras orales.

Publication types

  • Review

MeSH terms

  • Humans
  • Mouth Mucosa
  • Oral Ulcer*
  • Pain
  • Recurrence
  • Stomatitis, Aphthous* / diagnosis