APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

doi:10.1093/gerona/glaa131

. 2020 Oct 15;75(11):2231-2232.

doi: 10.1093/gerona/glaa131.

APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

Chia-Ling Kuo^{1

2}, Luke C Pilling^{2

3}, Janice L Atkins³, Jane A H Masoli^{3

4}, João Delgado³, George A Kuchel², David Melzer^{2

3}

Affiliations

¹ Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington.
² Center on Aging, University of Connecticut Health, Farmington.
³ Epidemiology and Public Health Group, University of Exeter Medical School, UK.
⁴ Department of Healthcare for Older People, Royal Devon and Exeter Hospital, UK.

PMID: 32451547
PMCID: PMC7314139
DOI: 10.1093/gerona/glaa131

APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

Chia-Ling Kuo et al. J Gerontol A Biol Sci Med Sci. 2020.

. 2020 Oct 15;75(11):2231-2232.

doi: 10.1093/gerona/glaa131.

Authors

Chia-Ling Kuo^{1

2}, Luke C Pilling^{2

3}, Janice L Atkins³, Jane A H Masoli^{3

4}, João Delgado³, George A Kuchel², David Melzer^{2

3}

Affiliations

¹ Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington.
² Center on Aging, University of Connecticut Health, Farmington.
³ Epidemiology and Public Health Group, University of Exeter Medical School, UK.
⁴ Department of Healthcare for Older People, Royal Devon and Exeter Hospital, UK.

PMID: 32451547
PMCID: PMC7314139
DOI: 10.1093/gerona/glaa131

No abstract available

Keywords: APOE; COVID-19; Genetic.

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Comment in

ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank.
Kuo CL, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D. Kuo CL, et al. J Gerontol A Biol Sci Med Sci. 2020 Sep 16;75(9):1801-1803. doi: 10.1093/gerona/glaa169. J Gerontol A Biol Sci Med Sci. 2020. PMID: 32623451 Free PMC article. No abstract available.
Comment on "ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank" by Kuo et al.
Nikogosov DA, Shevlyakov AD, Baranova AV. Nikogosov DA, et al. J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2233-2234. doi: 10.1093/gerona/glaa202. J Gerontol A Biol Sci Med Sci. 2020. PMID: 32803253 Free PMC article. No abstract available.
Commentary: APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort.
Kasparian K, Graykowski D, Cudaback E. Kasparian K, et al. Front Immunol. 2020 Sep 15;11:1939. doi: 10.3389/fimmu.2020.01939. eCollection 2020. Front Immunol. 2020. PMID: 33042114 Free PMC article. No abstract available.

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References

1. Atkins JL, Masoli JAH, Delgado J, Pilling LC, Kuo C-LC, Kuchel G, Melzer D. Preexisting comorbidities predicting severe COVID-19 in older adults in the UK biobank community cohort. medRxiv [Internet]. 2020. http://medrxiv.org/content/early/2020/05/08/2020.05.06.20092700.abstract. Accessed May 4, 2020.
1. Docherty AB, Harrison EM, Green CA, et al. Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO clinical characterisation protocol. medRxiv [Internet]. 2020. http://medrxiv.org/content/early/2020/04/28/2020.04.23.20076042.abstract. Accessed May 6, 2020.
1. Mao L, Wang M, Chen S, et al. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. JAMA Neurol. 2020. doi:10.1001/jamaneurol.2020.1127 - DOI - PMC - PubMed
1. Kuo C-L, Pilling LC, Atkins JL, Kuchel GA, Melzer D. ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants. medRxiv [Internet]. 2020. http://medrxiv.org/content/early/2020/02/13/2020.02.12.20022459.abstract. Accessed May 4, 2020. - PMC - PubMed
1. Farrer LA, Cupples LA, Haines JL, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. Journal of the American Medical Association. 1997;278:1349–1356. doi:10.1001/jama.1997.03550160069041z - DOI - PubMed

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[1] Atkins JL, Masoli JAH, Delgado J, Pilling LC, Kuo C-LC, Kuchel G, Melzer D. Preexisting comorbidities predicting severe COVID-19 in older adults in the UK biobank community cohort. medRxiv [Internet]. 2020. http://medrxiv.org/content/early/2020/05/08/2020.05.06.20092700.abstract. Accessed May 4, 2020.

[2] Atkins JL, Masoli JAH, Delgado J, Pilling LC, Kuo C-LC, Kuchel G, Melzer D. Preexisting comorbidities predicting severe COVID-19 in older adults in the UK biobank community cohort. medRxiv [Internet]. 2020. http://medrxiv.org/content/early/2020/05/08/2020.05.06.20092700.abstract. Accessed May 4, 2020.

[3] Docherty AB, Harrison EM, Green CA, et al. Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO clinical characterisation protocol. medRxiv [Internet]. 2020. http://medrxiv.org/content/early/2020/04/28/2020.04.23.20076042.abstract. Accessed May 6, 2020.

[4] Docherty AB, Harrison EM, Green CA, et al. Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO clinical characterisation protocol. medRxiv [Internet]. 2020. http://medrxiv.org/content/early/2020/04/28/2020.04.23.20076042.abstract. Accessed May 6, 2020.

[5] Mao L, Wang M, Chen S, et al. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. JAMA Neurol. 2020. doi:10.1001/jamaneurol.2020.1127 - DOI - PMC - PubMed

[6] Mao L, Wang M, Chen S, et al. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. JAMA Neurol. 2020. doi:10.1001/jamaneurol.2020.1127 - DOI - PMC - PubMed

[7] Kuo C-L, Pilling LC, Atkins JL, Kuchel GA, Melzer D. ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants. medRxiv [Internet]. 2020. http://medrxiv.org/content/early/2020/02/13/2020.02.12.20022459.abstract. Accessed May 4, 2020. - PMC - PubMed

[8] Kuo C-L, Pilling LC, Atkins JL, Kuchel GA, Melzer D. ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants. medRxiv [Internet]. 2020. http://medrxiv.org/content/early/2020/02/13/2020.02.12.20022459.abstract. Accessed May 4, 2020. - PMC - PubMed

[9] Farrer LA, Cupples LA, Haines JL, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. Journal of the American Medical Association. 1997;278:1349–1356. doi:10.1001/jama.1997.03550160069041z - DOI - PubMed

[10] Farrer LA, Cupples LA, Haines JL, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. Journal of the American Medical Association. 1997;278:1349–1356. doi:10.1001/jama.1997.03550160069041z - DOI - PubMed

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APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

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APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

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