From Tank to Treatment: Modeling Melanoma in Zebrafish

Cells. 2020 May 22;9(5):1289. doi: 10.3390/cells9051289.


Melanoma is the deadliest form of skin cancer and one of few cancers with a growing incidence. A thorough understanding of its pathogenesis is fundamental to developing new strategies to combat mortality and morbidity. Zebrafish-due in large part to their tractable genetics, conserved pathways, and optical properties-have emerged as an excellent system to model melanoma. Zebrafish have been used to study melanoma from a single tumor initiating cell, through metastasis, remission, and finally into relapse. In this review, we examine seminal zebrafish studies that have advanced our understanding of melanoma.

Keywords: Melanoma; genetics; melanocytes; microenvironment; modeling; xenografts; zebrafish.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Genetic Predisposition to Disease
  • Melanocytes / pathology
  • Melanoma / genetics
  • Melanoma / pathology*
  • Neural Crest / pathology
  • Zebrafish / physiology*