A Bird's-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

Cancers (Basel). 2020 May 23;12(5):1333. doi: 10.3390/cancers12051333.


: Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source.

Keywords: CAR-T cells; NK cells; blood cancer; cell-based therapy; dendritic cells; iPSC; macrophages; platelets; stem cells.

Publication types

  • Review