Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections

Int J Mol Sci. 2020 May 23;21(10):3689. doi: 10.3390/ijms21103689.


Viruses have evolved different strategies to hijack subcellular organelles during their life cycle to produce robust infectious progeny. Successful viral reproduction requires the precise assembly of progeny virions from viral genomes, structural proteins, and membrane components. Such spatial and temporal separation of assembly reactions depends on accurate coordination among intracellular compartmentalization in multiple organelles. Here, we overview the rearrangement and morphology remodeling of virus-triggered intracellular organelles. Focus is given to the quality control of intracellular organelles, the hijacking of the modified organelle membranes by viruses, morphology remodeling for viral replication, and degradation of intracellular organelles by virus-triggered selective autophagy. Understanding the functional reprogram and morphological remodeling in the virus-organelle interplay can provide new insights into the development of broad-spectrum antiviral strategies.

Keywords: intracellular organelles; rearrangement; remodeling; selective autophagy; virus.

Publication types

  • Review

MeSH terms

  • Animals
  • Autophagy*
  • Cytoplasmic Vesicles / metabolism
  • Cytoplasmic Vesicles / pathology
  • Golgi Apparatus / metabolism
  • Golgi Apparatus / pathology
  • Humans
  • Mitochondria / metabolism
  • Mitochondria / pathology
  • Virus Diseases / metabolism*
  • Virus Diseases / pathology