Complications and outcomes of SARS-CoV-2 in pregnancy: where and what is the evidence?

Hypertens Pregnancy. 2020 Aug;39(3):361-369. doi: 10.1080/10641955.2020.1769645. Epub 2020 May 26.

Abstract

Objectives: To add to the growing evidence on SARS-CoV-2 infection during pregnancy, so as to better inform clinical decision making and optimize patient outcomes.

Methods: A systematic search of relevant databases was perfomed on 25 March 2020 and a repeat search, on 10 April 2020. Reports of pregnant patients with SARS-CoV-2 infection at any time during their pregnancy were reviewed and summarized .

Results: We summarized the outcomes of a total of 155 pregnant women and 118 neonates. The evidence suggests a similar rate of severe COVID-19 cases in pregnant women and the general population. The frequency of cesarean deliveries is high, against guidelines recommendations.

Conclusion: Limited data on COVID-19 during preganacy, associated with a wide variation in the methodology make accurate data interpretation difficult.

Keywords: SARS-CoV-2; perinatal; pregnancy; vertical transmission.

Publication types

  • Systematic Review

MeSH terms

  • Betacoronavirus*
  • Cesarean Section / statistics & numerical data
  • Coronavirus Infections* / complications
  • Coronavirus Infections* / diagnosis
  • Coronavirus Infections* / therapy
  • Female
  • Humans
  • Pandemics*
  • Pneumonia, Viral* / complications
  • Pneumonia, Viral* / diagnosis
  • Pneumonia, Viral* / therapy
  • Pregnancy
  • Pregnancy Complications, Infectious* / diagnosis
  • Pregnancy Complications, Infectious* / therapy
  • Prognosis
  • Severity of Illness Index

Supplementary concepts

  • COVID-19
  • severe acute respiratory syndrome coronavirus 2