Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19

J Thromb Haemost. 2020 Aug;18(8):1859-1865. doi: 10.1111/jth.14929.

Abstract

The novel coronavirus disease of 2019 (COVID‐19) pandemic, as declared by the World Health Organization, is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV2). Cardiovascular disease and, in particular, venous thromboembolism (VTE) has emerged as an important consideration in the management of hospitalized patients with COVID‐19. The diagnosis of VTE using standardized objective testing is problematic in these patients, given the risk of infecting non‐COVID‐19 hospitalized patients and hospital personnel, coupled with the usual challenges of performing diagnostic testing in critically‐ill patients. Early reports suggest a high incidence of VTE in hospitalized COVID‐19 patients, particularly those with severe illness, that is similar to the high VTE rates observed in patients with other viral pneumonias, including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS‐CoV).

Keywords: SARS-CoV-2; anticoagulant; antithrombotic therapy; coronavirus disease 2019; hospitalization.

Publication types

  • Practice Guideline

MeSH terms

  • Aftercare
  • Anticoagulants / administration & dosage
  • Anticoagulants / adverse effects
  • Anticoagulants / therapeutic use
  • Betacoronavirus*
  • Biomarkers
  • COVID-19
  • COVID-19 Testing
  • Clinical Laboratory Techniques
  • Coronavirus Infections / blood
  • Coronavirus Infections / complications*
  • Coronavirus Infections / diagnosis
  • Critical Care
  • Cytokine Release Syndrome / blood
  • Cytokine Release Syndrome / etiology
  • Diagnostic Techniques, Cardiovascular
  • Disease Management
  • Drug Administration Schedule
  • Fibrin Fibrinogen Degradation Products / analysis
  • Hemorrhage / chemically induced
  • Hemorrhage / prevention & control
  • Humans
  • Inpatients
  • Mass Screening
  • Pandemics
  • Pneumonia, Viral / blood
  • Pneumonia, Viral / complications*
  • Point-of-Care Testing
  • Pulmonary Edema / blood
  • Pulmonary Edema / etiology
  • SARS-CoV-2
  • Sensitivity and Specificity
  • Thrombophilia / blood
  • Thrombophilia / drug therapy
  • Thrombophilia / etiology
  • Venous Thromboembolism / diagnosis
  • Venous Thromboembolism / etiology*
  • Venous Thromboembolism / prevention & control
  • Venous Thromboembolism / therapy

Substances

  • Anticoagulants
  • Biomarkers
  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D