Effect of calcium hydroxide mixed with lidocaine hydrochloride on postoperative pain in teeth with irreversible pulpitis and symptomatic apical periodontitis: a preliminary randomized controlled prospective clinical trial

Clin Oral Investig. 2021 Jan;25(1):203-210. doi: 10.1007/s00784-020-03354-w. Epub 2020 May 27.

Abstract

Objectives: To investigate the effect of calcium hydroxide mixed with lidocaine HCl on postoperative spontaneous pain.

Materials and methods: Sixty patients having irreversible pulpitis and symptomatic apical periodontitis with a preoperative spontaneous pain and percussion pain which was more than 50 on a visual analogue scale (100 mm VAS) were included in this study. After the preparation of the root canals, the patients were randomly distributed into two groups according to the calcium hydroxide vehicle, control group (mixed with saline) and calcium hydroxide mixed with lidocaine HCl (n = 30). Postoperative spontaneous pain scores were recorded by a VAS every day for a week. Data were analysed using one-way analysis of variance, chi-squared test and Mann-Whitney U tests (p = 0.05).

Results: The calcium hydroxide mixed with lidocaine HCl group resulted in significantly less pain compared with the calcium hydroxide mixed with saline group during days 1 to 4 (p < 0.05). There were no significant differences between the groups in terms of postoperative percussion pain levels (p > 0.05).

Conclusion: Within the limitations of this study, it can be concluded that the calcium hydroxide mixed with lidocaine HCl can be beneficial in reducing postoperative pain in teeth with irreversible pulpitis and symptomatic apical periodontitis.

Clinical relevance: The calcium hydroxide mixed with lidocaine HCl can be beneficial in reducing postoperative pain in teeth with irreversible pulpitis and symptomatic apical periodontitis.

Clinical registration number: TCTR20181121003.

Keywords: Apical periodontitis; Calcium hydroxide; Endodontics; Lidocaine; Postoperative pain.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Calcium Hydroxide / therapeutic use
  • Double-Blind Method
  • Humans
  • Lidocaine
  • Pain, Postoperative / drug therapy
  • Periapical Periodontitis* / drug therapy
  • Periapical Periodontitis* / surgery
  • Prospective Studies
  • Pulpitis* / drug therapy

Substances

  • Lidocaine
  • Calcium Hydroxide