Dual-targeting RNA Nanoparticles for Efficient Delivery of Polymeric siRNA to Cancer Cells

Chem Commun (Camb). 2020 Jun 18;56(49):6624-6627. doi: 10.1039/d0cc01848a.


A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.