Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series

doi:10.1093/jpids/piaa069

Case Reports

. 2020 Jul 13;9(3):393-398.

doi: 10.1093/jpids/piaa069.

Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series

Kathleen Chiotos^{1

2

3}, Hamid Bassiri^{2

3}, Edward M Behrens⁴, Allison M Blatz², Joyce Chang^{3

4}, Caroline Diorio⁵, Julie C Fitzgerald^{1

3}, Alexis Topjian^{1

3}, Audrey R Odom John^{2

3}

Affiliations

¹ Division of Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
² Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
³ Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁴ Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
⁵ Division of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

PMID: 32463092
PMCID: PMC7313950
DOI: 10.1093/jpids/piaa069

Free PMC article

Case Reports

Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series

Kathleen Chiotos et al. J Pediatric Infect Dis Soc. 2020.

Free PMC article

. 2020 Jul 13;9(3):393-398.

doi: 10.1093/jpids/piaa069.

Authors

Affiliations

¹ Division of Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
² Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
³ Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁴ Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
⁵ Division of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

PMID: 32463092
PMCID: PMC7313950
DOI: 10.1093/jpids/piaa069

Abstract

We present a series of 6 critically ill children with multisystem inflammatory syndrome in children. Key findings of this syndrome include fever, diarrhea, shock, and variable presence of rash, conjunctivitis, extremity edema, and mucous membrane changes.

Keywords: COVID-19; Kawasaki disease; SARS-CoV-2; multisystem inflammatory syndrome in children.

© The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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References

1. Riphagen S, Gomez X, Gonzalez-Martinez C, et al. . Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020; 395:1607–8. - PMC - PubMed
1. New York City Health Department. 2020 Health Alert #13: Pediatric Multi-System Inflammatory Syndrome Potentially Associated with COVID-19 Available at: https://www1.nyc.gov/assets/doh/downloads/pdf/han/alert/2020/covid-19-pe.... Accessed 7 May 2020.
1. Centers for Disease Control and Prevention. Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19) Available at: https://emergency.cdc.gov/han/2020/han00432.asp. Accessed 18 May 2020.
1. Dong Y, Mo X, Hu Y, et al. . Epidemiology of COVID-19 among children in China. Pediatrics 2020; 145: e20200702. - PubMed
1. Coronavirus disease 2019 in children— United States, February 12-April 2, 2020. Morbid Mortal Wkly Rep 2020; 69:422–426. - PMC - PubMed

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[1] Riphagen S, Gomez X, Gonzalez-Martinez C, et al. . Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020; 395:1607–8. - PMC - PubMed

[2] Riphagen S, Gomez X, Gonzalez-Martinez C, et al. . Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020; 395:1607–8. - PMC - PubMed

[3] New York City Health Department. 2020 Health Alert #13: Pediatric Multi-System Inflammatory Syndrome Potentially Associated with COVID-19 Available at: https://www1.nyc.gov/assets/doh/downloads/pdf/han/alert/2020/covid-19-pe.... Accessed 7 May 2020.

[4] New York City Health Department. 2020 Health Alert #13: Pediatric Multi-System Inflammatory Syndrome Potentially Associated with COVID-19 Available at: https://www1.nyc.gov/assets/doh/downloads/pdf/han/alert/2020/covid-19-pe.... Accessed 7 May 2020.

[5] Centers for Disease Control and Prevention. Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19) Available at: https://emergency.cdc.gov/han/2020/han00432.asp. Accessed 18 May 2020.

[6] Centers for Disease Control and Prevention. Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19) Available at: https://emergency.cdc.gov/han/2020/han00432.asp. Accessed 18 May 2020.

[7] Dong Y, Mo X, Hu Y, et al. . Epidemiology of COVID-19 among children in China. Pediatrics 2020; 145: e20200702. - PubMed

[8] Dong Y, Mo X, Hu Y, et al. . Epidemiology of COVID-19 among children in China. Pediatrics 2020; 145: e20200702. - PubMed

[9] Coronavirus disease 2019 in children— United States, February 12-April 2, 2020. Morbid Mortal Wkly Rep 2020; 69:422–426. - PMC - PubMed

[10] Coronavirus disease 2019 in children— United States, February 12-April 2, 2020. Morbid Mortal Wkly Rep 2020; 69:422–426. - PMC - PubMed

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Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series

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Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series

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