Abstract
In this article, we report the synthesis and use of iminosydnone-based profluorophores as bioorthogonal cleavable linkers for imaging applications. These linkers react with cycloalkynes via subsequent [3+2] cycloaddition and retro Diels-Alder reactions, allowing simultaneous release of two dyes in biological media.
MeSH terms
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Animals
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CHO Cells
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Catalysis
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Click Chemistry
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Cricetulus
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Cycloaddition Reaction
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Cyclooctanes / chemistry
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Fluorescence Resonance Energy Transfer
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Fluorescent Dyes / chemical synthesis*
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Fluorescent Dyes / metabolism
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Optical Imaging
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Palladium / chemistry
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Pyrazoles / chemistry
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Solvents / chemistry
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Structure-Activity Relationship
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Sydnones / chemical synthesis*
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Sydnones / metabolism
Substances
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Cyclooctanes
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Fluorescent Dyes
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Pyrazoles
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Solvents
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Sydnones
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Palladium