Successful application of antimicrobial photodynamic and photobiomodulation therapies for controlling osteoradionecrosis and xerostomia after laryngeal carcinoma treatment: A case report of full oral rehabilitation

Photodiagnosis Photodyn Ther. 2020 Sep:31:101835. doi: 10.1016/j.pdpdt.2020.101835. Epub 2020 May 25.


We present a clinical case where a conservative treatment based on photonics [antimicrobial Photodynamic Therapy (aPDT) associated to Photobiomodulation therapy (PBMT)] of a patient with osteoradionecrosis (ORN) due to radiotherapy treatment of a laryngeal cancer. As a result of this combined treatment the ORN was controlled (e.g. the necrosis, infection and suppuration disappeared). Moreover, the symptoms reported by the patient (pain and xerostomia) also diminished along with the repair of oral mucosa. In future cases this combined therapy (e.g. PBM therapy and the aPDT) will be further examined.

Keywords: Head and neck cancer; Osteoradionecrosis; Photobiomodulation therapy; Photodynamic therapy; Xerostomia.

Publication types

  • Case Reports

MeSH terms

  • Anti-Infective Agents*
  • Carcinoma*
  • Head and Neck Neoplasms*
  • Humans
  • Laryngeal Neoplasms* / drug therapy
  • Laryngeal Neoplasms* / radiotherapy
  • Low-Level Light Therapy*
  • Osteoradionecrosis* / etiology
  • Osteoradionecrosis* / therapy
  • Photochemotherapy* / methods
  • Photosensitizing Agents / therapeutic use
  • Xerostomia*


  • Anti-Infective Agents
  • Photosensitizing Agents