SnapShot: Ferroptosis

Cell. 2020 May 28;181(5):1188-1188.e1. doi: 10.1016/j.cell.2020.04.039.


Ferroptosis is a regulated form of cell death that occurs when phospholipids with polyunsaturated fatty acyl tails are oxidized in an iron-dependent manner. Research in recent years has uncovered complex cellular networks that induce and suppress lethal lipid peroxidation. This SnapShot provides an overview of ferroptosis-related pathways, including relevant biomolecules and small-molecule modulators regulating them.

MeSH terms

  • Cell Death
  • Ferroptosis / genetics*
  • Ferroptosis / physiology*
  • Humans
  • Iron / metabolism*
  • Lipid Peroxidation / physiology
  • Oxidation-Reduction
  • Phospholipids / metabolism


  • Phospholipids
  • Iron